This site is intended for US health care professionals only.

IMPORTANT SAFETY INFORMATION

This site is intended for US healthcare professionals only.

WARNING: ABUSE AND DEPENDENCE

  • CNS stimulants (amphetamines and methylphenidate-containing products), including Vyvanse, have a high potential for abuse and dependence. Assess the risk of abuse prior to prescribing; monitor for signs of abuse and dependence during therapy.
Full Safety Information Below

Vyvanse® (lisdexamfetamine dimesylate) is indicated for the treatment of moderate to severe binge eating disorder (B.E.D.) in adults. Vyvanse is not indicated or recommended for weight loss. Use of other sympathomimetic drugs for weight loss has been associated with serious cardiovascular adverse events. The safety and effectiveness of Vyvanse for the treatment of obesity have not been established.

Binge Eating Disorder in Adults Resource Center

Use these educational resources to learn about Binge Eating Disorder (B.E.D.) in adults and the diagnostic criteria.

Educational downloads

  • Adult Binge Eating Disorder Patient Screener

    Use this B.E.D. screener to help you begin the evaluation process with adult patients that may have Binge Eating Disorder.

    Download
  • Discussion Guide for Adult Patients with Binge Eating Disorder

    Use this guide to help you begin a dialogue about B.E.D. with adult patients.

    Download

Additional resources

  • B.E.D.Pro Resource™

    Stay up to date on the latest news and information about B.E.D. in adults.

    Register

Educational videos

  • How does the prevalence of B.E.D. in adults compare to that of other eating disorders?

    Learn how the prevalence of B.E.D. compares to the prevalence of other eating disorders in adults.

    Watch

  • To make a diagnosis of B.E.D. in adult patients, what are the essential features?

    Get information about the essential features for a diagnosis of B.E.D. in adult patients.

    Watch

  • How does the prevalence of B.E.D. in US adults compare among different races/ethnicities?

    See how the prevalence of B.E.D. compares among races and ethnicities in adults.

    Watch

  • How is B.E.D. in adults distinct from overeating and obesity?

    See the ways that B.E.D. in adults is distinct from overeating and obesity.

    Watch

  • How is B.E.D. distinct from bulimia nervosa in adults?

    See the ways that B.E.D. is distinct from bulimia nervosa in adults.

    Watch

  • What is the age of onset for B.E.D. in adults?

    Get information about the age of onset for B.E.D. in adults.

    Watch

  • Is there a relationship between obesity and B.E.D. in adults?

    Learn about the relationship between obesity and B.E.D. in adults.

    Watch

  • How can clinicians start the conversation with adults in their practice about Binge Eating Disorder?

    See how you can begin an effective conversation with your adult patients about B.E.D.

    Watch

You can either give your adult patients these educational materials, or you can use them when speaking with your adult patients to help facilitate an informed and meaningful conversation.

Educational downloads

  • Proper Use of Prescription Stimulants Brochure

    Help your adult patients understand the proper use of stimulant medications.

    Download
  • Vyvanse Brochure

    You can use this brochure with your adult patients who have recently been prescribed Vyvanse.

    Download

Shire Resources

  • Shire Cares

    Shire Cares is dedicated to assisting patients with limited financial resources.

    Find out more

Organizations

IMPORTANT SAFETY INFORMATION

WARNING: ABUSE AND DEPENDENCE

  • CNS stimulants (amphetamines and methylphenidate-containing products), including Vyvanse, have a high potential for abuse and dependence. Assess the risk of abuse prior to prescribing; monitor for signs of abuse and dependence during therapy.
  • Contraindications

    Patients should not take Vyvanse if they are:

    • hypersensitive to amphetamines or other ingredients of Vyvanse. Anaphylactic reactions, Stevens-Johnson Syndrome, angioedema, and urticaria have occurred.
    • taking monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of an increased risk of hypertensive crisis.
  • Warnings and Precautions
    • Prior to and during treatment assess for the presence of cardiac disease. Avoid use in patients with known structural cardiac abnormalities, cardiomyopathy, serious heart arrhythmia, coronary artery disease, and other serious heart problems. Note that sudden death, stroke and myocardial infarction have been reported in adults with CNS stimulants at recommended doses, as well as sudden death in children and adolescents with structural cardiac abnormalities and other serious heart problems while taking CNS stimulants at recommended doses. Evaluate patients with exertional chest pain, unexplained syncope, or arrhythmias while taking Vyvanse.
    • CNS stimulants can cause increases in blood pressure (mean increase about 2-4 mm Hg) and heart rate (mean increase about 3-6 bpm). Monitor all patients for tachycardia and hypertension.
    • Prior to treatment assess for the presence of bipolar disorder. CNS stimulants may cause psychotic or manic symptoms in patients with no prior history, or exacerbation of symptoms in patients with pre-existing psychosis.
    • CNS stimulants, including Vyvanse, are associated with peripheral vasculopathy, including Raynaud’s phenomenon. Signs and symptoms are usually intermittent and mild; very rare sequelae include digital ulceration and/or soft tissue breakdown. Observe patients for new numbness, pain, skin color change, or sensitivity to temperature in fingers and toes. Further evaluation may be required, including referral.
    • Increased risk of serotonin syndrome when co-administered with serotonergic agents (eg, SSRIs, SNRIs, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John’s Wort), but also during overdosage situations. The potential for a pharmacokinetic interaction exists with co-administration of CYP2D6 inhibitors which may increase the risk with increased exposure to the active metabolite of Vyvanse (dextroamphetamine). In these situations, consider an alternative non-serotonergic drug or an alternative drug that does not inhibit CYP2D6. If serotonin syndrome occurs, discontinue Vyvanse and any concomitant serotonergic agents immediately and initiate supportive treatment.
  • Adverse Reactions
    • The most common adverse reactions (≥5% and at least twice the rate of placebo) reported in clinical trials of adults with moderate to severe B.E.D. were: dry mouth, insomnia, decreased appetite, increased heart rate, feeling jittery, constipation, and anxiety.
  • Pregnancy and Lactation
    Vyvanse may cause fetal harm. Breastfeeding is not recommended during Vyvanse treatment.
  • Other Considerations
    • Safety and effectiveness in patients <18 years with B.E.D. have not been established.

INDICATION AND LIMITATION OF USE

Vyvanse (lisdexamfetamine dimesylate) is indicated for the treatment of moderate to severe binge eating disorder (B.E.D.) in adults. Vyvanse is not indicated or recommended for weight loss. Use of other sympathomimetic drugs for weight loss has been associated with serious cardiovascular adverse events. The safety and effectiveness of Vyvanse for the treatment of obesity have not been established.

Please click here for Full Prescribing Information, including Boxed WARNING regarding Potential for Abuse and Dependence.

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